Man may not escape from corona maze game that he has started

It is now quite clear that India in particular and the world at large may not escape from the corona maze game that it had started/created.  We have adopted measures similar to that of a moth to a flame; self-defeating, self-destructive and self-denying.  We took measures and strategies that are more brutal to people than to the virus. 

We have to realize that the virus is also intelligent and so shall be its creator – evolution.  

We need to ask several fundamental questions to WHO (World health Organization) because WHO is keep learning about the virus day by day and no one knows which class; pre-KG or UKG education WHO has competed by now with reference to novel coronavirus. 

Most of the questions we must attempt to answer also from the premise of evolution and only then we can truly reflect how unwise WE are in taking several measures to contain the virus.

Why should a deadly virus SARS-CoV2 or otherwise called as novel coronavirus must evoke pathology similar to that of flu viruses? 

Is there any true pathogenic viruses would ever produce various pathological conditions similar to that of flu viruses and leaves no unique fingerprint pathology of the new virus? 

Does that mean the coronavirus is as harmless as flu virus?  Should we interpret, the novel coronavirus is displaying mullerian mimicry at the pathological level so that human would get fooled easily and go chill towards the virus and the virus can go scout free, which our GREAT SCIENTISTS have blocked?    

Is there any similarity between novel coronavirus and flu viruses?

SARS-CoV-2 is a beta-coronavirus with single ≈30 kb strand of RNA as its genome. On the other hand, the infection flu is caused by a group of viruses from different families of RNA viruses with the genome size of ≈14 kb encoded in eight distinct strands of RNA, and also affect human cells in a different way when compared to coronavirus. 

The point of concern is that novel coronavirus has the largest genome among all RNA viruses and this has led the scientists to presume that the virus may have some proofreading mechanism to reduce mutation and stabilise the genome.   It means the virus would undergo mutation less slowly but can adapt with its host quickly. 

What makes the story more complicated is not just the less mutation possibility of the virus or the rapid adaptation but the viral replication along with its prolonged active phase in extra human sources like plastic, wet surface etc.

The viral replication of novel coronavirus appears to be quite fast and more so in the nasal region.  Whether pre-symptomatic or asymptomatic sufferers besides those who show complete clinical symptoms would discharge greater viral load and transmit the virus is still not clear.

The uniqueness of novel coronavirus is that it has both reduced mutation rate and higher replication ability collectively may be increasing its fitness and not the elimination.  

Another complication is about the survival period of the virion in extra human sources like water, wet surfaces, plastic surfaces etc.  It is proven that the virion would be active for several hours to days in certain extra human sources like plastic.  Similarly the RNA of the virus is also detected in several such sources.  The exact size of the virion required to cause infection is not clearly known.  In a country like India, at least three times higher positivity of the virus in our population may exist outside the reach of testing as against the number of tested positive population.  

If someone has contracted the virus from the extra human sources and are transmitting the virus to others means the source shall remain hidden forever but a few floater positive cases alone we may proudly quarantine or treat. 

We also must ask the question of why only 1 in every 10 or more screened only turn positive in India. 

In India, the viral spread and infection appears to follow ‘mosaic’ pattern and not uniform and even pattern.  The point to be noted here is that the diverse immune responses and varied susceptibility of the host population in India may be limiting the spread of the virus in a mosaic pattern.

Everyone in any given geographic area if get exposed to the virus simultaneously, all of them needs not contract the virus now would show the symptoms of the disease. In India, such situation looks far too high than many other countries.

It means the virus may enter in some but leaves quickly and infect only a few.  The reason for the above is quite strange and mysterious.  But the real problem is the vast majority of people in India may be thinking that they may fall under small risk/vulnerable population group than the dominant resilient population to the virus.  

We have spent too long and lost too much in the maze game with novel coronavirus mostly because we followed either the virus or applied the conventional epidemiological theories that sleeps inside the pages of some text books, cannot be applied to a country like India.   

Every life form would interact in two directions to bring changes such as – the change that happens within and attempts to bring the changes outside of the species. 

The changes ‘within’ in this context can be grouped under mutation and the changes created outside come under the definition of infectivity, viral replication etc.  

When we talk about the changes i.e., ‘outside’ of the virus, we must include the two important elements such as the ‘the total human environment’ and the wide variety of ‘microbes’ (both commensal and pathogenic) that harbours within the human system. 

The new pathogen has to encounter both the components, must maintain its replication, finds a new host, reduce mutation or accelerate most favourable mutation, able to be active in extra human sources for long time with the hope to get a new host, win and or weaken its competitors (other microbes in the human system) etc. 

The above challenges are true for all pathogens in general.  But the curious question is why this ‘so called deadly coronavirus’ produces almost similar or shared pathology of flu viruses and not unique pathology that can be associated to the uniqueness and novelty of the virus?   

Is the world over cried due to the simple fact that the virus is new and hence whatever the virus is going to do are also new?  Therefore lockdown is the only measure to contain the virus? 

What the so called decisive Modi has achieved for India through lockdown?

It looks like the novel coronavirus has come to stay with us and not to leave us.  Therefore the maze game that we have started with novel coronavirus is not going to lead us anywhere. 

In a country like India, man to man transmission alone may not be taking place but the virion from extra human sources also may be spreading the virus, may be at lesser extent. 

Further the mosaic type of transmission of the virus and the infection in our population clearly indicates that we have less to worry about the virus, however needs to be careful.

The worst pathology seen in co-morbid patients suggest that there may be ‘some’ competition happening between novel coronavirus and other microbes in such patients collectively triggering immune flare up leading to death, in some cases. 

The high replication and transmission of the virus doesn’t support the virus to be a true pathogen.   But we are still after the virus, with a catapult in hand with the hope that coronavirus would be eliminated and curve will be flattened. 

Nothing is going to work with the virus.  The measures of the government should not be against the life and livelihood of people and no such measure would help any government to win such war. 

Police brutality may work against people but not against virus.  Hope Modi will realize the pain of millions of people who elected him twice. 

India needs weak, multiparty coalition government, not single party majority rule which will destroy the federal structure and plurality of India.  Coronavirus has revealed the autocratic face of democracy and not the benevolent face of democracy.  Let us not question the democracy, but change the political party that we support.